Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma
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چکیده
منابع مشابه
The prognostic significance of MCL1 copy number gain in esophageal squamous cell carcinoma
Background MCL1 copy number variations have been reported to be associated with cancer prognosis in several cancers. However, the role of MCL1 gain has not yet been determined in esophageal squamous cell carcinomas (ESCC). Methods Fluorescence in situ hybridization (FISH) for MCL1 was performed on 262 ESCC samples using tissue microarray (TMA). Results The median age of ESCC patients was 62...
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Hypopharyngeal cancers are often diagnosed at an advanced stage and have a poor prognosis. Even when they are diagnosed at an operable stage, surgery often results in substantial morbidity and decreased patients' quality of life. Although the endoscopic diagnosis of early hypopharyngeal cancer is difficult, recent developments in advanced imaging endoscopy have enabled easier diagnosis of these...
متن کاملCD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.
BACKGROUND Both L-type amino acid transporter 1 (LAT1) and CD98 are strongly expressed in primary human cancer and play essential roles in tumor growth. We studied the clinicopathological significance of LAT1 and CD98 expression in hypopharyngeal squamous cell carcinoma (SCC). METHODS A total of 70 patients with stage III/IV disease were retrospectively reviewed. Immunohistochemical staining ...
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Oropharyngeal squamous cell carcinomas (OPSCC) are common, have poor outcomes, and comprise two biologically and clinically distinct diseases. While OPSCC that arise from human papillomavirus infections (HPV+) have better overall survival than their HPV- counterparts, the incidence of HPV+ OPSCC is increasing dramatically, affecting younger individuals which are often left with life-long co-mor...
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ژورنال
عنوان ژورنال: Genes, Chromosomes and Cancer
سال: 2016
ISSN: 1045-2257
DOI: 10.1002/gcc.22425